IndraLab

Statements


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"Furthermore, in both models of apoptosis, NO releasing compounds dose-dependently reduced : (a) the number of the titratable thiol groups (cysteine residues) of c-Jun; (b) induction of AP-1 DNA binding activity; (c) AP-1-driven transactivation of the CD95L promoter; and (d) caspase activation."

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"NO attenuated the binding of activator protein-1 to the 12-O-tetradecanoylphobol-13-acetate-responsive element (TRE) in the MCP-1 promoter region."

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"NO prevents the activity of Jun N-terminal kinase1 (JNK1) by S nitrosylation that leads to reduction in Bcl-2 phosphorylation."

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"Nitric oxide inhibits IgE dependent cytokine production and Fos and Jun activation in mast cells."