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KCNH2 activates Cell Survival. 2 / 3
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"Compared to control cells treated with the solvent (0.2% DMSO; n = 4; XREF_FIG), hERG siRNA reduced cell viability to 25.4 +/-2.1% (n = 5; p = 0.0008; XREF_FIG), whereas scrambled siRNA (24 h) did not significantly affect cell death (n = 4; p = 0.26; XREF_FIG)."
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"On the contrary, scFv-hERG1-Cys added for 24 hours to HEK 293 hERG1 cells, which over-express hERG1, or to different cancer cell lines (triple negative breast cancer cell line, MDA-MB231, pancreatic ductal adenocarcinoma cell lines, PANC-1 and MIAPaCa-2, colorectal cancer cell line, HCT-116) endowed with high endogenous hERG1 expression, significantly decreased cell viability (Figure 4C)."
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