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Irbesartan inhibits JUN. 5 / 5
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"In addition, in a patient with metastatic colon cancer, irbesartan inhibits activator protein 1 (AP-1) DNA binding and the JUN gene, resulting in a complete functional radiological resolution of the disease, showing its enormous potential in cancer treatment [78]."
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"Thus, inhibition of FOS and JUN by Nadroparin and Irbesartan may have potential applications as anti-inflammatory options for RSV infection."
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"However, the role of irbesartan in reducing chemotherapy resistance in PDAC has not been reported.To explore the target of irbesartan, we performed RNA-sequencing and found that c-Jun, a canonical member of the AP-1 family, was significantly repressed by irbesartan in PDAC."
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"Mechanistically , we found that irbesartan decreased c-Jun expression by inhibiting the Hippo / YAP1 pathway and further overcame chemotherapy resistance in PDAC ."
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"Further luciferase assays indicated that irbesartan notably repressed the transcriptionally activity of the c-Jun promoter in PDAC (Fig. 4G)."
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