IndraLab

Statements

reach
"Mechanistically, BG effectively suppressed LPS-induced microglial activation and pro-inflammatory response by targeting Kv1.3 and CBR1.Highly destructive or pathological neuroinflammation is associate[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
36058290
reach
"LPS and I+T both increased several Ca 2+ -related molecules (Orai3, Stim1, Trpm7), and K + channels and their regulators (Calm1, Kcna3, Kcnj2, Mtmr6, Rest)."
30087595
reach
"Previous research indicated that LPS-activated RAW 264.7 macrophages exhibited a 1.6-fold elevation in functional Kv1.3 than control [39] ."
27744058
reach
"When we monitored the effect of CPZ on Kv1.3 channel expression in mPFC, we found that LPS injection increased the Kv1.3 integrated density (sum of the mean fluorescence intensity of each pixel in a region of interest) in Iba1(+) microglia, a response that was inhibited in the presence of CPZ (Figure 3c,d)."
39435609
reach
"Compared to the unstimulated BMDMs (MOCK), the LPS-primed BMDMs produced basal Kv1.3 currents, which was not affected by genetic ablation of TWIK2 channel ( Fig. 6 A, C)."
37898389
reach
"We demonstrated that CPZ acutely blocked Kv1.3 currents and suppressed the LPS-induced upregulation of Kv1.3, suggesting that Kv1.3 is the primary microglial target of CPZ."
40340862
eidos
"In line with these observations , in our study , LPS increases the Kv1.3 expression and cytokine secretion ."
33864815
eidos
"Interestingly , while LPS also increases KV1.3 and reduces P2X4 expression on microglia in vivo , both KV1.3 and P2X4 expression increase in parallel in the setting of ischemic stroke as shown by our laboratory on acutely isolated microglia from the infarcted brain hemisphere of mice subjected to ischemic stroke and by other groups on rodent and human microglia by immunohistochemistry or qPCR [ 5,12,43 -46 ] ."
33356832