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Sirolimus inhibits RELA. 11 / 11
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"Accordingly, rapamycin reduced the nuclear localized NF-κB p65 ( Fig. 3 D)."
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"Western blot results showed that rapamycin and/or anthocyanin significantly inhibited HIF-1α and p–NF–κB p65/NF-κB p65 protein expression levels ( Fig. 4 H and I)."
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"The administration of rapamycin suppressed the expression of p-PI3K, p-Akt, and NF-κB subunit p65 in WERI-Rb-1 cells."
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"As shown in Fig. 3 C, rapamycin treatment reduced the DNA-bound nuclear fraction of NFκ-B p65 from H9c2 cells as well as mouse hearts."
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"We found that in HaCaT cells induced with TNF-I +/-, Rapamycin inhibited key steps in activation of central pro inflammatory factor NF-I (o) B : II (o) BI +/- phosphorylation and degradation; and nucl[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Compared with Tan-IIA alone, Tan-IIA combined with rapamycin further reduced the transport of NF-κB p65 into the nucleus."
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"We found that in HaCaT cells induced with TNF-I +/-, Rapamycin inhibited key steps in activation of central pro inflammatory factor NF-I (o) B : II (o) BI +/- phosphorylation and degradation; and nucl[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"PCA, Bay 11-7085, Akt inhibitor, rapamycin and N -acetylcysteine inhibited lipopolysaccharide caused increase in the NF-kappaB p65 to DNA binding activity."
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"Moreover, immunofluorescent staining showed that rapamycin reduced the accumulation of p65 in the nucleus after ox-LDL treatment for 30 h. mTOR knockdown decreased LOX-1 protein production and IkappaBalpha phosphorylation induced by ox-LDL."
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"Moreover, a combination of rapamycin (80 nM) and MPA (20 nM) inhibited the TNF-alpha-induced nuclear localization of NF-kappaB p65 in HaCaT cells when compared with individual drug treatments and other combinations of the two drugs."
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"The rapamycin treatment significantly decreased the level of phospho-NF-kappaB p65 protein in the IL-23-treated cells, suggesting that mTOR functioned as an upstream regulator to mediate NF-kappaB p65 activation in IL-23-stimulated TFCs."
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