IndraLab

Statements

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"D-myo-inositol-1,4,5-triphosphate and phosphatidyl-4,5-inositol-biphosphate depletion are involved in TASK channel inhibition, whereas diacylglycerols and phosphatidic acids directly inhibit TREK channels."
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"We then held the reconstituted TREK1 protein concentration constant and altered the phospholipid composition of the proteoliposomes, demonstrating that the anionic lipid 1-palmitoyl-2-oleoyl PA (POPA) causes a dose-dependent increase in TREK1 activity while the zwitterionic lipid 1-palmitoyl-2-oleoyl PE (POPE) inhibits TREK1 function (Fig. 2a–c)."
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