IndraLab

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USP3 increases the amount of ACOT7. 3 / 3
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"Tao et al. found that ubiquitin-specific protease 3 (USP3) upregulated the expression of the ACOT7 protein through a deubiquitination mechanism, whereas downregulation of USP3 markedly elevated the expression of ACSL4 and promoted ferroptosis in NSCLC cells [71]."
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"Mechanistically, USP3 upregulated ACOT7 protein expression through deubiquitination."
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"To conclude, USP3 upregulated ACOT7 protein expression through deubiquitination, thereby repressing ferroptosis in NSCLC cells and enhancing DDP resistance."
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