IndraLab

Statements

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"In this study, there were no biologically significant changes in caspase activity following co-administration of TCDD and LPS; caspase-1 activity was reduced at day 14 in mice treated with TCDD and LP[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12878042
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"While LPS increased inflammasome assembling and caspase-1 activation, AC treatment inhibited caspase-1 activation in D-HAEC (P <= 0.05)."
31935365
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"65 Thus, incubation of LPS stimulated macrophages with an IKK inhibitor, Bay11-7082, blocks NLRP3 induction and caspase 1 activation by ATP."
29158945
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"Knockdown of MKK3 by siRNA in wild type BMDMs improved mitochondrial membrane potential , reduced LPS induced caspase-1 activation and attenuated cytokine secretion ."
25697779
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"The translocation of rCTB-YVAD is a prerequisite for the inhibition of LPS induced caspase-1 activation and subsequent IL-1beta secretion."
24884459
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"To further investigated whether CRD mediated inhibition of LPS induced caspase-1 activation and IL-1beta and IL18 expression was mediated by modulating the expression or function of NLRP3 inflammasome[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
28962083
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"(PTX±DEX/AZI) inhibited LPS- and R848-induced caspase-1 activation in newborn monocytes, whereby the combinations (PTX+DEX) and (PTX+AZI) exerted greater inhibition of LPS-induced caspase 1 activation than the single agents (S6 Fig)."
29715306
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"In conclusion, we suggest that CYT and quercetin decrease LPS induced inflammatory cytokine production by inhibiting NF-kappaB and caspase-1 activation."
21108840
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"This includes Peptide 19-2.5 inhibiting intracellular LPS-induced caspase-1 activation and HMGB1."
34349763
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"Meanwhile, suppression of NOX2 derived iROS production blocked LPS elicited caspase-1 activation and IL-1beta maturation in IL-10 -/- microglia in vitro and in vivo."
31940754
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"LPS injection causes liver damage as indicated by elevated ALT and AST levels, and a significant upregulation of both hepatic mRNA and protein levels for all the inflammasome components including NALP3, and two cytokine targets of caspase-1, IL-1beta and IL-18."
26936883
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"Furthermore , caspase-1 activity levels were significantly increased by LPS / ATP stimulation of human monocytes ( P = 0.010 ; Fig 6C ) , and significantly suppressed by KW3110 pre-treatment ( P = 0.001 ; Fig 6C ) ."
32804985
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"As shown in XREF_FIG, LPS induced caspase-1 activation was decreased by treatment of PA at a dose dependent manner, consistent with the result on IL-1beta production (XREF_FIG)."
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"Additionally, HSP70 intervention reversed LPS-induced mitochondrial destabilization, inhibited activation of the NLRP3 inflammasome, caspase-1, GSDMD and GSDMD-N, and decreased pyroptosis."
36439706
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"The results showed that LPS induced caspase-1 activation was much lower in cells expressing ULK1/2A than ULK1-WT, and expression of phosphorylation mimicking ULK1 (ULK1/2E) alone could induce caspase-1 activation (XREF_FIG)."
29196462
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"Scotton et al. [XREF_BIBR] demonstrated that stimulation of human monocytes with IL-13 (M2 polarization) is associated with downregulation of caspase-1 expression and a reduction in LPS induced caspase 1 activity, with resulting reduced cleavage of pro-IL-1beta and diminished secretion of LPS induced IL-1beta."
22281427
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"In contrast to glyburide, SB203580 or knockdown of p38alpha MAPK significantly attenuated LPS induced decrease in LC3-II while reducing LPS induced activation of caspase-1 and increase of IL-1beta and IL-18 (XREF_FIG and S5, F and G)."
29196462
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"BHB also counteracted the LPS and ATP promoted cell migration by suppressing the activation of caspase-1 and the maturation of IL-1beta."
30218403
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"In the presence of latrunculin-b or colchicine, LPS induced caspase-1 activation and IL-18 production were reduced, suggesting a direct role of a dysfunctional actin cytoskeleton during inflammasome activation in Wdr1 mutant cells (XREF_FIG)."
26008898
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"inhibited LPS and nigericin induced caspase-1 activation with an IC 50 of 150 nM ( Figure 1D ) ."
32954500
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"Our present study demonstrated that KM inhibited LPS and ATP induced pyroptosis and the release of IL-1beta/18 in J774A.1 cells by inhibiting the activation of GSDMD and caspase-1 and the assembly of NLRP3 inflammasome."
30952097
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"LPS inhibits lacrimal gland secretion by activating caspase 1, and IL-1beta activates the ERK pathway to inhibit lacrimal gland protein secretion and aqueous tear production."
18566460
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"The importance of the IL-1 system for high-dose, LPS induced septic shock is reflected by the LPS resistance of the IL-1beta converting enzyme deficient mice, known to have neither detectable serum levels of IL-1beta nor IL-1alpha upon LPS challenge."
20975042
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"Furthermore, chronic LPS stimulation induces similar reduction of caspase-1 activation and IL-1beta production in Ifnar2 -/- BMDMs (XREF_SUPPLEMENTARY)."
26412089
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"Moreover, in comparison to the infection with wt, chi12253 LPS strain did lead to a lower IL-1beta release from cells and decreased the level of caspase-1 cleavage into a mature form."
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"This protein synthesis is likely mediated by NF-kappaB, as pretreatment of cells with the proteasome inhibitor MG132, or the IkappaB kinase inhibitor Bay 11-7085 before LPS stimulation blocks the ability of LPS to potentiate the activation of caspase-1 by the P2X7R."
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"YopJ dependent caspase-1 activation and IL-1beta secretion were inhibited when BMDMs were treated with LPS prior to infection with Y. pseudotuberculosis XREF_BIBR or Y. pestis XREF_BIBR."
21533069
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"Under these conditions , EC144 inhibited LPS and nigericin induced caspase-1 activation with an IC50 of 150 nM ( Figure 1D ) ."
32954500
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"Interestingly, prolonged LPS stimulation reduced caspase-1 processing in a time dependent fashion, and caspase-1 maturation was dramatically reduced in lysates of ATP treated BMDMs that had been stimulated with LPS for 24h (XREF_FIG)."
26412089
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"Keller et al. [XREF_BIBR] reported that although caspase-1 is not involved in IL1alpha maturation, the lipopolysaccharide stimulated release of IL1alpha is drastically reduced in caspase-1 -/- monocytes and keratinocytes."
24511556
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"Inhibitory effect of rCTB-YVAD on LPS induced caspase-1 activation and subsequent IL-1beta secretion in Caco-2 cells."
24884459
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"Consistent with the previous findings [XREF_BIBR], we found that WT Listeria induced less caspase-1 processing and cell death in NLRP3-KO macrophages compared to WT macrophages (XREF_FIG), suggesting that NLPR3 is partially involved in caspase-1 activation after Listeria infection and that absence of LPS priming reduces but does not abrogate caspase-1 activation or cell death in these macrophages."
20490635
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"The results showed that pretreatment with Teuvincenone F and then LPS simulation blocked caspase-1 cleavage and IL-1beta production in a dose dependent manner in mouse peritoneal macrophages."
28878677
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"In three separate assay systems, LPS induced lethality, LPS and IL-4-induced IL-1beta cleavage, and LPS and IL-4-induced DNA fragmentation, heterozygotes showed a phenotype similar to the wt, arguing [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12667444
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"Our results show that LPS primed macrophages pre-incubated with the HSM extract causes decreased activation of caspase-1 in ATP treated macrophages."
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"Western blot analysis indicates that LPS treatment induced degradation of caspase-1 precursor, which was inhibited by treatment CYT or quercetin."
21108840