IndraLab

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"In contrast to glyburide, SB203580 or knockdown of p38alpha MAPK significantly attenuated LPS induced decrease in LC3-II while reducing LPS induced activation of caspase-1 and increase of IL-1beta and IL-18 (XREF_FIG and S5, F and G)."
29196462
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"Here we show that the level of NLRP3 expression is not the only factor limiting caspase-1 activation, and that LPS may augment inflammasome function through additional mechanisms.We exposed wild-type [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
22898390
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"The results showed that LPS induced caspase-1 activation was much lower in cells expressing ULK1/2A than ULK1-WT, and expression of phosphorylation mimicking ULK1 (ULK1/2E) alone could induce caspase-1 activation (XREF_FIG)."
29196462
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"Consistent with the previous findings [XREF_BIBR], we found that WT Listeria induced less caspase-1 processing and cell death in NLRP3-KO macrophages compared to WT macrophages (XREF_FIG), suggesting that NLPR3 is partially involved in caspase-1 activation after Listeria infection and that absence of LPS priming reduces but does not abrogate caspase-1 activation or cell death in these macrophages."
20490635
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"In addition, lipopolysaccharide (LPS) administration into the Arc of mice attenuated the food intake and weight of mice, indicating the crucial role of elevated inflammation (particularly caspase-1) in the Arc in the feeding behavior of mice (Supplemental Fig. 2)."
34601428
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"LPS-primed Txnip BMDMs stimulated with MSU, ATP, or R-837 impaired the maturation of caspase-1 and IL-1β, suggesting that TXNIP is essential for NLRP3 inflammasome activation."
37475970
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"DHA pretreatment in lipopolysaccharide-stimulated bone-marrow-derived macrophages blocked caspase-1 activation and IL-1 secretion[72]."
39351184
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"In addition, lipopolysaccharide (LPS) administration into the Arc of mice attenuated the food intake and weight of mice, indicating the crucial role of elevated inflammation (particularly caspase-1) in the Arc in the feeding behavior of mice (Supplemental Fig. 2)."
34601428
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"(PTX±DEX/AZI) inhibited LPS- and R848-induced caspase-1 activation in newborn monocytes, whereby the combinations (PTX+DEX) and (PTX+AZI) exerted greater inhibition of LPS-induced caspase 1 activation than the single agents (S6 Fig)."
29715306
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"Moreover, treatment of LPS/ATP-stimulated Caco-2 cells with NQ-2 and NQ-3 potently inhibited CASP-1 activity and expression."
35462013
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"This protein synthesis is likely mediated by NF-kappaB, as pretreatment of cells with the proteasome inhibitor MG132, or the IkappaB kinase inhibitor Bay 11-7085 before LPS stimulation blocks the ability of LPS to potentiate the activation of caspase-1 by the P2X7R."
16301671
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"In three separate assay systems, LPS induced lethality, LPS and IL-4-induced IL-1beta cleavage, and LPS and IL-4-induced DNA fragmentation, heterozygotes showed a phenotype similar to the wt, arguing [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12667444
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"The FAM-FLICA caspase activation assay results showed that LPS/Nig treatment caused caspase-1 activation, while MSCs-Exo treatment inhibited caspase-1 activation in AM (Fig. 4A)."
38349749
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"In the presence of latrunculin-b or colchicine, LPS induced caspase-1 activation and IL-18 production were reduced, suggesting a direct role of a dysfunctional actin cytoskeleton during inflammasome activation in Wdr1 mutant cells (XREF_FIG)."
26008898
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"Silencing caspase-1 by using siRNA couldsuppressing EMT caused by LPS in HCC, thus inhibited theinvasion and metastasis.As the first-line systematic therapy for advanced HCC, sorafenib has been known to repress the progression of HCC.16 In our study, we demonstrated that sorafenib coulddecrease caspase-1 expression at the transcriptional level andalso suppress LPS mediated caspase-1 upregulation, whichcontributed to the repression of invasion."
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"While LPS increased inflammasome assembling and caspase-1 activation, AC treatment inhibited caspase-1 activation in D-HAEC (P <= 0.05)."
31935365
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"As expected, JNK inhibitor dramatically blocked LPS-induced caspase-1 processing in both Nlrp3 −/− macrophages expressing NLRP3-T346M and human primary monocytes ( Figures 4 G and S5 F)."
28943315
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"As illustrated in (Figure 7A–7E), the coadministration of MINO and LPS effectively suppressed the activation of NLRP3, caspase-1, IL-1β, and IL-18 proteins."
38329438
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"In addition, intracellular LPS has been reported to induce caspase-11-dependent non-canonical NLRP3 inflammasome activation.8 36 37 Our results showed that tivantinib treatment also inhibited transfected LPS-induced caspase-1 cleavage and IL-1β release in a dose-dependent manner (Figures 2C and 2D)."
36843841
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"Notably, modified LPS in OMVs strongly attenuated the proteolytic processing of pro‐caspase 1 and GSDMD in THP‐1 cells."
37329166
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"The importance of the IL-1 system for high-dose, LPS induced septic shock is reflected by the LPS resistance of the IL-1beta converting enzyme deficient mice, known to have neither detectable serum levels of IL-1beta nor IL-1alpha upon LPS challenge."
20975042
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"It was observed that treatment of LPS-primed BMDMs with doliroside A blocked caspase-1 activation and IL-1β maturation in a concentration-dependent manner ( Fig. 6 A–C)."
25064339
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"As shown in XREF_FIG, LPS induced caspase-1 activation was decreased by treatment of PA at a dose dependent manner, consistent with the result on IL-1beta production (XREF_FIG)."
23213315
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"Western blot analysis indicates that LPS treatment induced degradation of caspase-1 precursor, which was inhibited by treatment CYT or quercetin."
21108840
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"Moreover, AMS21 attenuated LPS-induced elevations in CASP1 (p = 0.000028), NLRP3 (p = 0.000055) and PYCARD (p = 0.018303), while pre-treatment with WRW4 blocked these beneficial properties of the agonist (CASP1 (p = 0.037574), NLRP3 (p = 0.000062), PYCARD (p = 0.006172))."
37947648
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"We observed that treatment of LPS-primed BMDMs with doliroside A blocked caspase-1 activation and IL-1β maturation in a concentration-dependent manner."
25064339
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"LPS inhibits lacrimal gland secretion by activating caspase 1, and IL-1beta activates the ERK pathway to inhibit lacrimal gland protein secretion and aqueous tear production."
18566460
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"To further investigated whether CRD mediated inhibition of LPS induced caspase-1 activation and IL-1beta and IL18 expression was mediated by modulating the expression or function of NLRP3 inflammasome[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"LPS injection causes liver damage as indicated by elevated ALT and AST levels, and a significant upregulation of both hepatic mRNA and protein levels for all the inflammasome components including NALP3, and two cytokine targets of caspase-1, IL-1beta and IL-18."
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"Fig. 4 E and 4F shows that pretreatment of LPS-stimulated BV2 cells with TP-5 decreased NLRP3, ASC and caspase-1 production to alter LPS-induced neuroinflammatory responses."
37121113
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"Moreover, LPS-induced caspase-1 activation and IL-1β secretion are markedly decreased in caspase-11-deficient mice (Kayagaki et al., 2013; Wang et al., 1998)."
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"Furthermore , caspase-1 activity levels were significantly increased by LPS / ATP stimulation of human monocytes ( P = 0.010 ; Fig 6C ) , and significantly suppressed by KW3110 pre-treatment ( P = 0.001 ; Fig 6C ) ."
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"Additionally, HSP70 intervention reversed LPS-induced mitochondrial destabilization, inhibited activation of the NLRP3 inflammasome, caspase-1, GSDMD and GSDMD-N, and decreased pyroptosis."
36439706
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"Moreover, in comparison to the infection with wt, chi12253 LPS strain did lead to a lower IL-1beta release from cells and decreased the level of caspase-1 cleavage into a mature form."
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"65 Thus, incubation of LPS stimulated macrophages with an IKK inhibitor, Bay11-7082, blocks NLRP3 induction and caspase 1 activation by ATP."
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"Surprisingly, overexpression of M13L in differentiated THP-1 cells resulted in decreased LPS-induced caspase-1 activation ( Johnston et al., 2005 )."
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"We indeed observed that pretreatment of LPS-primed bone-marrow-derived macrophages (BMDMs) with DHA blocked caspase-1 activation and IL-1β maturation in a dose-dependent manner ( Figures 1 A and 1B )."
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"The translocation of rCTB-YVAD is a prerequisite for the inhibition of LPS induced caspase-1 activation and subsequent IL-1beta secretion."
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"Dysbiosis disrupted gut integrity, altering the jejunal adherens junction complex E-cadherin/β-catenin and decreasing Trefoil Factor (TFF)-3. SY administration elevated LPS serum levels, activated the inflammatory inflammasome cascade TLR4/NLRP3/ASC/cleaved-activated caspase-1 to mature IL-1β and IL-18, and activated caspase-11 and gasdermin-N, indicating pyroptosis and increased intestinal permeability."
38490351
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"Inhibitory effect of rCTB-YVAD on LPS induced caspase-1 activation and subsequent IL-1beta secretion in Caco-2 cells."
24884459
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"Meanwhile, suppression of NOX2 derived iROS production blocked LPS elicited caspase-1 activation and IL-1beta maturation in IL-10 -/- microglia in vitro and in vivo."
31940754
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"DM-fBEVs-induced caspase-11/caspase-1 activation and inflammation were inhibited by the LPS neutralizer PMB, suggesting that LPS is a major effector derived from DM-fBEVs that triggered inflammation in tubular cells."
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"In conclusion, we suggest that CYT and quercetin decrease LPS induced inflammatory cytokine production by inhibiting NF-kappaB and caspase-1 activation."
21108840
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"Interestingly, prolonged LPS stimulation reduced caspase-1 processing in a time dependent fashion, and caspase-1 maturation was dramatically reduced in lysates of ATP treated BMDMs that had been stimulated with LPS for 24h (XREF_FIG)."
26412089
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"Furthermore, chronic LPS stimulation induces similar reduction of caspase-1 activation and IL-1beta production in Ifnar2 -/- BMDMs (XREF_SUPPLEMENTARY)."
26412089
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"YopJ dependent caspase-1 activation and IL-1beta secretion were inhibited when BMDMs were treated with LPS prior to infection with Y. pseudotuberculosis XREF_BIBR or Y. pestis XREF_BIBR."
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"Scotton et al. [XREF_BIBR] demonstrated that stimulation of human monocytes with IL-13 (M2 polarization) is associated with downregulation of caspase-1 expression and a reduction in LPS induced caspase 1 activity, with resulting reduced cleavage of pro-IL-1beta and diminished secretion of LPS induced IL-1beta."
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"In this study, there were no biologically significant changes in caspase activity following co-administration of TCDD and LPS; caspase-1 activity was reduced at day 14 in mice treated with TCDD and LP[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12878042
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"Keller et al. [XREF_BIBR] reported that although caspase-1 is not involved in IL1alpha maturation, the lipopolysaccharide stimulated release of IL1alpha is drastically reduced in caspase-1 -/- monocytes and keratinocytes."
24511556
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"The results showed that pretreatment with Teuvincenone F and then LPS simulation blocked caspase-1 cleavage and IL-1beta production in a dose dependent manner in mouse peritoneal macrophages."
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"We found that caspase-1 activity was significantly inhibited by preincubation with the GBE both in LPS and nigericin, as well as in cells treated only with nigericin (p < 0.0001; Figure 4a,b)."
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"Moreover, LPS + LeTx-induced IL-1β secretion was inhibited in Nlrp3 , Asc , and Casp1 BMDMs, whereas wild-type and Casp11 BMDMs secreted comparable amounts of IL-1β in the culture supernatants (Fig. 1M)."
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"This includes Peptide 19-2.5 inhibiting intracellular LPS-induced caspase-1 activation and HMGB1."
34349763
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"BHB also counteracted the LPS and ATP promoted cell migration by suppressing the activation of caspase-1 and the maturation of IL-1beta."
30218403
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"Our results show that LPS primed macrophages pre-incubated with the HSM extract causes decreased activation of caspase-1 in ATP treated macrophages."
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"Knockdown of MKK3 by siRNA in wild type BMDMs improved mitochondrial membrane potential , reduced LPS induced caspase-1 activation and attenuated cytokine secretion ."
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