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Chloroform inhibits KCNH2. 6 / 8
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"Chloroform dependent block of HERG channels was voltage dependent with a loss of inhibition at more positive membrane potentials."
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"In addition, we further confirmed that trichloromethane inhibited hERG channel in a concentration dependent manner with an IC 50 of 4.0 mM in HEK 293 cells stably expressing hERG gene, consistent with[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"A report recently demonstrated that trichloromethane inhibited hERG channel ( Scholz et al., 2006 )."
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"The methanolic extract of the TCM herbal drug Coptidis rhizoma (Coptis chinensis Franch., Ranunculaceae) reduced the peak tail hERG current by 31.7 +/- 2.0% at 100 microg/mL."
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"A previous report demonstrated that trichloromethane can inhibit hERG current ( Scholz et al., 2006 )."
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"Chloroform concentrations of 1.25 mM reduced HERG tail currents by approximately 20% and IC 50 of inhibition yielded 4.97 mM."
16647228