IndraLab

Statements

USP25 activates RIGI. 5 / 5
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"The deubiquitinase USP21 targets RIG-I for deubiquitination, thus dampening interferon production and activation of IFN responsive genes in response to RNA viruses."
24493797
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"However, our studies explain that USP25 negatively modulates RIG-I and MDA5-dependent type I IFN signaling."
24260525
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"USP17 and USP25 also deubiquitinate RIG-I in a different manner; that is, USP17 stabilizes RIG-I by K48-deubiquitination, while USP25 inhibits RIG-I degradation by K63-deubiquitination [37, 38] ."
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"For example, ubiquitin-specific peptidase 3 (USP3), USP21, and cylindromatosis lysine 63 deubiquitinase (CYLD) modulate RIG-I signaling by removing K63-polyubiquitin chains (Cui et al., 2014; Fan et al., 2014)."
40126553
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"Ubiquitylation events are reversible processes, and, accordingly, several deubiquitylating enzymes, in particular ubiquitin specific peptidase 3 (USP3), USP21 and CYLD lysine 63 deubiquitinase (CYLD), modulate RIG-I signalling by removing K63-polyubiquitin chains, although with unique kinetics."
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