IndraLab

Statements

USP25 activates DDX58. 5 / 5
| 5
reach
"The deubiquitinase USP21 targets RIG-I for deubiquitination, thus dampening interferon production and activation of IFN responsive genes in response to RNA viruses."
24493797
reach
"Ubiquitylation events are reversible processes, and, accordingly, several deubiquitylating enzymes, in particular ubiquitin specific peptidase 3 (USP3), USP21 and CYLD lysine 63 deubiquitinase (CYLD), modulate RIG-I signalling by removing K63-polyubiquitin chains, although with unique kinetics."
31792373
reach
"However, our studies explain that USP25 negatively modulates RIG-I/MDA5-dependent type I IFN signaling."
24260525
reach
"USP17 and USP25 also deubiquitinate RIG-I in a different manner; that is, USP17 stabilizes RIG-I by K48-deubiquitination, while USP25 inhibits RIG-I degradation by K63-deubiquitination [37, 38] ."
33922750
reach
"However, our studies explain that USP25 negatively modulates RIG-I and MDA5-dependent type I IFN signaling."
24260525