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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

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INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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Notch inhibits CYLD. 3 / 3

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"Therefore, we reasoned that fibulin-3 stimulation of Notch could downregulate CYLD and indirectly activate NF-kappaB."

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"Similarly, CYLD is downregulated by Notch and Hes1 in T-cell acute lymphoblastic lymphoma (T-ALL), thus leading to constitutive NF-kappaB activation."

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"Notch activation in CYLD siRNA transfected cells was normalised to cells transfected with non silencing siRNA."

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INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...

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Statements

Notch inhibits CYLD. 3 / 3

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