IndraLab

Statements

DHM inhibits NLRP3. 5 / 5
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"These data indicated that the NLRP3 inflammasome was inhibited by DHM treatment."
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"We determined whether DHM intervention decreased NLRP3 protein, leading to its target protein (pro caspase 1) not being converted to mature caspase-1."
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"In the present study, we demonstrated that DHM could inhibit the activation of the NLRP3 inflammasome to protect the liver against LPS stimulation."
35073994
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"In contrast, DHM attenuated ileum mucosal damage and oxidative stress, maintained the barrier function, and inhibited NLRP3 inflammasome and TLR4 and NF-kappaB signalling pathway activation."
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"Therefore, this study explored the protective mechanisms of DHM against E. coli LPS induced ileum injury in chickens through antioxidants, alleviating intestinal lesions, inhibiting apoptosis and NLRP3 inflammasome, and analysed possible downstream targets of drug involving TLR4 and NF-kappaB signalling pathway."
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