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DHM inhibits NLRP3. 16 / 16
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"These findings indicate that mitophagy likely plays a pivotal role in DHM-mediated blockade of endothelial NLRP3 inflammasome activation.As shown in Fig. 6, DHM pretreatment significantly reduced the mRNA expression of NLRP3 and IL-1β (Fig. 6D and E), indicating that DHM may also regulate the priming process (signal 1) of NLRP3 inflammasome activation."
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"In the present study, we demonstrated that DHM effectively suppressed activation of the NLRP3 inflammasome in APP/PS1 mice."
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"Specifically, DHM prevents the formation of NLRP3 inflammasomes and the assembly of ASC (adapter protein), effectively inhibiting the activation of inflammatory vesicles."
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"These data indicated that the NLRP3 inflammasome was inhibited by DHM treatment."
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"DHM markedly abrogates intracellular ROS and mtROS (mitochondrial ROS) generation, further blocking NLRP3-dependent pyroptosis in vascular ECs (90)."
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"Although additional mechanisms by which DHM inhibits the NLRP3 inflammasome cannot be entirely dismissed, molecular investigations conducted herein support the proposal that DHM promotes endothelial mitophagy to maintain normal mitochondrial functionality, thereby preventing NF-κB from activating the NLRP3 inflammasome and reducing the subsequent release of IL-1β."
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"Therefore, this study explored the protective mechanisms of DHM against E. coli LPS induced ileum injury in chickens through antioxidants, alleviating intestinal lesions, inhibiting apoptosis and NLRP3 inflammasome, and analysed possible downstream targets of drug involving TLR4 and NF-kappaB signalling pathway."
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"For example, DHM treatment reduces the activation of NLRP3 inflammasome and lipopolysaccharide (LPS)-induced TLR4/NF-κB signaling pathway [29]."
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"Wang YC and colleagues demonstrated that DHM treatment could inhibit the activation of NLRP3 inflammasome and subsequent pyroptosis [93] ."
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"To examine whether DHM inhibits NLRP3 inflammasomes through a decrease in levels of Aβ, specific immunostaining identifying amyloid protein was performed with antibody 4G8, which recognizes the Aβ fragment."
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"However, experimental results with rats by Matouk et al. (2022) indicated that DHM mitigates MTX-induced liver toxicity by reducing oxidative stress and inhibiting the TLR4/NF-κB and NLRP3/caspase-1 pathways."
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"We determined whether DHM intervention decreased NLRP3 protein, leading to its target protein (pro caspase 1) not being converted to mature caspase-1."
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"DHM inhibits the NLRP3 inflammasome to mitigate doxorubicin-caused cardiotoxicity via activating SIRT1 ( Sun et al., 2020 )."
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"In contrast, DHM attenuated ileum mucosal damage and oxidative stress, maintained the barrier function, and inhibited NLRP3 inflammasome and TLR4 and NF-kappaB signalling pathway activation."
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"Next, we examined whether DHM treatment directly inhibits activation of the NLRP3 inflammasome."
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"In the present study, we demonstrated that DHM could inhibit the activation of the NLRP3 inflammasome to protect the liver against LPS stimulation."
35073994