IndraLab

Statements


USP7 activates BMI1. 3 / 3
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"Knockdown of USP7 or USP11 causes increased turnover of chromatin bound MEL18 and BMI1, whereas over-expression of the USPs reduces the levels of mono- and poly-ubiquitination of these proteins."

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"Importantly, knockdown of either USP7 or USP11 reduces the total and chromatin bound pool of BMI1 and MEL18, and the effects can be mitigated by inhibiting proteasome function."

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"Knockdown of USP7 or USP11 causes increased turnover of chromatin bound MEL18 and BMI1, whereas over-expression of the USPs reduces the levels of mono- and poly-ubiquitination of these proteins [XREF_BIBR]."