IndraLab

Statements

USP7 activates NLRP3 inflammasome complex assembly. 2 / 2

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reach

"Depletion of USP7 abolished H O -mediated pyroptosis and ROS induction and inactivated NLRP3 inflammasome activation in rat chondrocytes (100)."

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reach

"The study showed that treatment with P22077, an inhibitor of both USP7 and USP47, impairs NLRP3 inflammasome activation in macrophages, leading to the inhibition of IL-1β, IL-18, and caspase-1 cleavage and release, as well as pyroptotic cell death."

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INDRA sources:

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IndraLab

Statements

USP7 activates NLRP3 inflammasome complex assembly. 2 / 2

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