IndraLab

Statements

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"This revealed that USP11 did not facilitate the malignant progression of CRC by inhibiting apoptosis, which was different from a previous study that reported that USP11 knockdown induced apoptosis [22]."
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"* P < 0.05 MiR-132-3p constrains cell growth and metastasis and increases apoptosis by decreasing USP11 in colorectal cancer cells To study the function of miR-132-3p / USP11 axis on colorectal cancer progression , HCT116 and SW480 cells were transfected with miR-NC , miR-132-3p mimic , miR-132-3p mimic + pcDNA , or USP11 overexpression vector ."
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"Knockdown of USP11 significantly increased GEM sensitivity and apoptosis in BLCA cells, whereas USP11 overexpression had the opposite effect (Figure S12)."
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"Flow cytometry and TUNEL assay revealed that the overexpression of HOXC5 rescued USP11 knockdown-induced apoptosis in human SSCs (Fig. 7H–K)."
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"Hence, USP11/Nrf2 positive feedback loop inhibited mitochondrial apoptosis of CRC cells by activating Nrf2/ARE signaling pathway, thus promoting CRC progression."
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"The overexpression of MYC effectively reversed the increased GEM sensitivity and induced apoptosis caused by USP11 knockdown (Figure S13K-O)."
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"Collectively, these data imply that overexpression of HOXC5 can rescue proliferation, DNA synthesis, and apoptosis caused by USP11 knockdown in human SSCs."
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"In contrast, HOXC5 overexpression reversed the effect of proliferation and apoptosis induced by USP11 silencing."
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"Cell apoptosis assays showed that silencing USP11 increased the apoptosis rate of HCC cells (Fig. S4A/C), while overexpressing USP11 inhibited these processes (Fig. S4B)."
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"Additionally, USP11 interacts with XIAP to suppress apoptosis in breast cancer cells [35]."
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"In addition, the combination treatment inhibition of USP11 and autophagy enhanced the apoptosis of HCC cells and inhibited the tumor growth in mice more effective than either treatment alone."
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"In the apoptosis assays, overexpression of SREBF1 reduced the increased apoptosis caused by USP11 suppression (Fig. S4D-E), whereas the opposite effect was observed in Huh7 cells (Fig. S4F)."
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