IndraLab

Statements

reach
"OTUB2 enables the initiation of HR by suppressing the excessive accumulation of 53BP1 and RAP80 in an early phase of the DDR [XREF_BIBR, XREF_BIBR]."
30831436
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"Thus, the RNF8-RNF168 axis primarily suppresses HR and promotes non-HR-type DSB repair, e.g. NHEJ, and OTUB2 enables the initiation of HR by suppressing the excessive accumulation of 53BP1 and RAP80 in an early phase of the DDR."
26983989
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"OTUB1 binds Ubc13 (UBE2N) to inhibit K63-linked-ubiquitination of chromatin in DSB repair, whereas its ohnolog, OTUB2, shows much lower affinity for Ubc13 and instead promotes HR by interacting with another novel ohnolog, L3MBTL1."
28177072