IndraLab

"Several are transmembrane proteins such as HRD1. xref , xref , xref , xref , xref , xref Others are cytoplasmic E3 ligases that have been demonstrated to be involved in ERAD. xref , xref , xref , xref , xref , xref HRD1 forms ERAD E3 ligase complex with SEL1L and DERLIN-1 and promotes unfolded protein recognition and ubiquitination, recruitment to the retrotranslocon, retrotranslocation, extraction, and transport to the proteasome for degradation. xref , xref Several endogenous substrates for SEL1L/HRD1-mediated ERAD, including IRE1 and p53, have been identified. xref , xref , xref , xref , xref Although it has been shown that expression of HRD1 is significantly downregulated in breast cancer tissues, xref it is possible that other ERAD E3 ligases beside BRCA1 are functional in the breast cancer cells."

"SEL1L associates with Derlin-1, -2, p97, and HRD1, as well as with additional proteins that remain to be identified, some or all of which may also play a role in dislocation."

"The US11 ERAD pathway is the better characterized and helped identify the Derlin-1 and SEL1L complex, emphasizing the utility of these viral genes in defining ERAD components."