IndraLab

Statements

INS inhibits KCNQ1. 6 / 6
| 6
reach
"We found that insulin suppressed KCNQ1 / KCNE1 currents, in which KCNE1 played an essential role in the effects of insulin.3 The phosphatidylinositol 3kinase (PI3K)/Akt pathway was responsible for the effects of insulin, while the MEK and ERK pathway was not."
25483581
reach
"A hypothetical model of insulin mediated suppression of KCNQ1 and KCNE1 currents."
25483581
reach
"Insulin substitution fully prevented the diabetes induced changes in I (Ks), KvLQT1 and MinK, however, the changes in I (to), Kv4.3, and Kv1.4 were only partially diminished by insulin."
17182020
reach
"Acute application of insulin suppressed the KCNQ1 and KCNE1 currents and phosphorylated Akt and extracellular signal regulated kinase (ERK), the two major downstream effectors, in a concentration dependent manner."
24068254
reach
"Insulin suppresses IKs (KCNQ1 and KCNE1) currents, which require beta-subunit KCNE1."
24068254
reach
"We have previously reported that acute application of insulin suppresses the KCNQ1 and KCNE1 currents that play an important role in terminating ventricular action potential."
28882596