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UCHL3 activates IFN-I. 7 / 7
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"Interestingly, overexpression of UCHL3 robustly promoted IFN-I mediated antiviral activity, as shown by a significantly decreased VSV-GFP signaling."
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"Taken all together, our data suggest that UCHL3 positively regulates IFN-I mediated signaling pathway and antiviral activity.Deubiquitinases play important roles in controlling signaling pathways rela[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"However, the roles of most of deubiquitinases in regulating IFN-I antiviral signaling are still largely unexplored.Here, we report that UCHL3 positively regulates IFN-I antiviral signaling pathway."
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"Our data showed that knockdown of endogenous UCHL3 inhibited IFN-I induced transcription activation of all three ISGs, strongly suggesting that UCHL3 positively regulates IFN-I signaling pathway.Given[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"If doing so, one could understand that UCHL3 promotes IFN-I signaling by deneddylation of Cullin1 and inhibition of SCF beta and TrCP complex activity.To test this hypothesis, cells were transfected w[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Furthermore, we reveal that UCHL3 increases levels of SCF beta-TrCP substrates and enhances IFN-I mediated signaling and antiviral activity."
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"This finding suggests that UCHL3 could target either TYK2 itself or IFN-I receptors (IFNAR1 and IFNAR2), which are the direct proteins upstream of TYK2 as well as the first signaling proteins in IFN-I[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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