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CCCP inhibits STING1. 7 / 7
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"Our findings clearly demonstrate that CCCP suppresses the early step of STING pathway via inducing mitochondrial fission."
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"Although we found that ionomycin-induced mitochondrial fission and inhibition of the STING pathway are also reduced in DRP1-deficient MEFs, there is a distinction between this phenomenon and CCCP-indu[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Noticing that CCCP has been shown to trigger mitochondria fission, we tested whether CCCP suppresses the STING pathway by inducing mitochondria fission."
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"However, pretreatment with CCCP effectively abolished the activation of STING and NF-κB p65 induced by Pol β knockdown."
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"Next, we examined whether CCCP could suppress the activation of STING pathway triggered by STING ligands other than DMXAA."
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"Thus, we investigated whether CCCP inhibits STING pathway via inducing mitochondrial fission."
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"Collectively, these results indicate that mitochondria fission mediated by DRP1 is the crucial effector mechanism by which CCCP suppresses the STING pathway.Although emerging evidence indicates the im[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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