IndraLab

Statements

SCN2A binds ANK3. 3 / 4
1 | 3
sparser
"Previous studies have demonstrated that AnkG interacts with Nav1.2, a primary ion channel involved in the initiation of an action potential ( xref , xref ), as well as with Ndel1, a dynein regulator that functions in selective sorting and polarity maintenance at the AIS ( xref , xref )."
35850303
sparser
"This apparent multisite binding mode immediately sparked our interest in exploring E-cadherin-AnkG complex assembly, as this is distinct from previously known binding modes of both reported AnkG-Nav1.2 and AnkG-Neurofascin complexes and from E-cadherin-mediated complexes (e.g., E-cadherin-β-catenin, E-cadherin-p120 catenin), which exhibit strict 1:1 stoichiometry between two protein partners."
37891324
sparser
"A previous report showed that the interaction between ankyrin-G and Nav1.2 sodium channels is modulated by protein kinase CK2-mediated phosphorylation of the ankyrin-binding motif of Nav1.2 ( xref )."
34099188