IndraLab

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USP4 decreases the amount of SMAD7. 2 / 2
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"Also, detection of the expression levels of TGF-betaR1and Smad7 proteins showed that the down-regulation of USP4 inhibited the expression of TGF-betaR1 and promoted the expression of Smad7."

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"In addition, inhibition of Ubiquitin carboxyl-terminal hydrolase 4 (USP4) decreased TGF- beta1 induced expression of TbetaR-I and reversed the altered expression of Smad7, Smurf2, ZO-1 and Vimentin."