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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

USP4 decreases the amount of SMAD7. 2 / 2

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"Also, detection of the expression levels of TGF-betaR1and Smad7 proteins showed that the down-regulation of USP4 inhibited the expression of TGF-betaR1 and promoted the expression of Smad7."

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"In addition, inhibition of Ubiquitin carboxyl-terminal hydrolase 4 (USP4) decreased TGF- beta1 induced expression of TbetaR-I and reversed the altered expression of Smad7, Smurf2, ZO-1 and Vimentin."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...