IndraLab

Statements

USP18 inhibits STAT1. 9 / 11
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"USP18 negatively regulates the activation of STAT1 upon interaction with IFNAR2 ."
32039148
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"USP18 negatively regulates the activation of STAT1 upon interaction with IFNAR2 (Malakhova et al., 2006)."
32039148
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"XREF_BIBR, XREF_BIBR To asses whether STAT1 or STAT2, which are both upregulated by USP18 inhibition (XREF_FIG), are implicated in the upregulation of Bim, DP5 and PUMA mRNA expression in USP18 silenced cells, we inhibited in parallel USP18 and STAT1 or STAT2 in INS-1E cells by use of specific siRNAs."
23152055
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"We further found that microglial Usp18 negatively regulates the activation of Stat1 and concomitant induction of interferon induced genes, thereby terminating IFN signaling."
25896511
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"Interestingly, IL-17A pretreatment increased the expression of suppressor of cytokine signaling (SOCS) 1, SOCS3 and USP18, which were also the ISGs negatively regulating activity of ISGF3."
35144643
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"Therefore, knockdown USP18 leads to prolonged and enhanced the activity of STAT1, and upregulated expression of many ISGs."
29285303
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"Silencing of USP18 by specific siRNA attenuated the pSTAT1 suppression by Ach."
27716962
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"Silencing USP18 prolongs the phosphorylated state of signal transducer and activator of transcription 1 (STAT1) and enhances the expression of ISGs in response to IFN-alpha [XREF_BIBR]."
25798824
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"Of note, USP18 knockdown did not increase pSTAT1 in response to IFN-alpha before 24 h; these findings are consistent with previous observations."
27009955