IndraLab

Statements

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"The block of HERG by trifluoperazine was use dependent, exhibiting more rapid onset and greater steady-state block at higher frequencies of activation; there was partial relief of the block with decreasing frequency."
15722405
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"Thioridazine, perphenazine, trifluoperazine, and chlorpromazine blocked hERG potassium channels with the following IC (50) values : IC (50) values were 224 +/- 42 nM for thioridazine, 1003 +/- 71 nM for perphenazine, 1406 +/- 124 nM for trifluoperazine, and 1561 +/- 281 nM for chloropromazine."
16051556
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"The IC (50) for a trifluoperazine block of HERG current progressively decreased according to depolarization : IC (50) values at -40, 0, and +40 mV were 21.6, 16.6, and 9.29 microM, respectively."
15722405