IndraLab

Statements

USP3 deubiquitinates H2AX. 4 / 5
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"USP3, USP51 and USP16 de-ubiquitinate H2A/H2AX with varying degrees of specificity [47–49]."
31769469
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"In addition, USP3 deubiquitinates histone H2A and H2AX, negatively regulating the recruitment of DNA damage repair proteins ."
36712126
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"Further studies revealed that in addition to uH2A, USP3 also deubiquitinates conjugate Ub-γH2AX (variant H2A) at K13-15."
38773075
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"During DNA damage repair, USP3 negatively regulates the accumulation of BRCA1 and 53BP1 at DNA break sites by deubiquitinating Ub-conjugates of γH2AX (Ub-γH2AX) and uH2A [26]."
39996778