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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

CD28 increases the amount of OTUB1. 2 / 2

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"The inhibition of CD28 costimulation by CTLA4-Ig treatment blocked Otub1 expression and sustained GRAIL expression, and this effect could be reversed by the addition of agonist anti-CD28 Ab (XREF_FIG)."

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"For this, CD28 co-stimulation via IL-2/mTOR-dependent pathways induces the expression of the deubiquitinase Otubain-1 (OTUB1) [177], which destabilize and promote GRAIL degradation [178] (Figure 2)."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...