IndraLab

Statements

CD28 increases the amount of OTUB1. 2 / 2
| 2
reach
"The inhibition of CD28 costimulation by CTLA4-Ig treatment blocked Otub1 expression and sustained GRAIL expression, and this effect could be reversed by the addition of agonist anti-CD28 Ab (XREF_FIG)."
19414743
reach
"For this, CD28 co-stimulation via IL-2/mTOR-dependent pathways induces the expression of the deubiquitinase Otubain-1 (OTUB1) [177], which destabilize and promote GRAIL degradation [178] (Figure 2)."
| PMC