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USP8 increases the amount of BCL2. 2 / 2

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"The results of western blot indicated that knockdown of USP8 down-regulated the expression of Cyclin D1, CDK4, CDK6, p-AKT, and Bcl2, and up-regulated the expression of Bax."

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"Jing et al. extended the apoptotic activity of USP8 in cholangiocarcinoma cells, where the silencing of USP8 was reported to decrease Bcl-2 expression and increase Bax, cleaved Caspase 3, and cleaved Caspase 9 expression and thereby triggering apoptosis (18)."

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IndraLab

Statements

USP8 increases the amount of BCL2. 2 / 2

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