IndraLab

Statements


USP8 deubiquitinates GJA1. 4 / 4
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"USP8 reduces both multiple monoubiquitination and polyubiquitination of Cx43 to prevent autophagy mediated degradation."

"The ubiquitin-specific protease USP8 deubiquitinates and stabilizes Cx43"

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"Ectopic overexpression of USP8 was found to promote the loss of both Cx43 monoubiquitination and polyubiquitin chains linked via Lys48 or Lys63, which was associated with increased Cx43 protein levels."

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"USP8 interacts with and deubiquitinates Cx43, removing monoubiquitin moieties as well as K63- and K48 linked ubiquitin chains."