IndraLab

Statements

USP8 deubiquitinates GJA1. 4 / 5
1 | 4
reach
"It is reported that Cx43 is ubiquitinated and degraded by autophagy whereas this Cx43 autophagy-mediated degradation is enhanced by knockdown of USP8 in breast cancer."
33600786
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"USP8 reduces both multiple monoubiquitination and polyubiquitination of Cx43 to prevent autophagy mediated degradation."
29626091
reach
"Ectopic overexpression of USP8 was found to promote the loss of both Cx43 monoubiquitination and polyubiquitin chains linked via Lys48 or Lys63, which was associated with increased Cx43 protein levels."
31501970
reach
"USP8 interacts with and deubiquitinates Cx43, removing monoubiquitin moieties as well as K63- and K48 linked ubiquitin chains."
30126257