IndraLab

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Thymol inhibits RELA. 3 / 3
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eidos
"Commercial standardized Thymus vulgaris extract ( thymol 0.3 % w / w ) was found to downregulate the activity of p65 and modulate the release of IL-1beta and IL-8 , which play roles part in the inflammatory mechanisms in the H460 human lung cancer cell line [ 187 ] ."
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"Thymol at a dose of 10, 20, and 40 μg/mL also prevented the activation of the MAPKs I-B, NF-B p65, ERK, JNK, and p38 in mouse mammary epithelial cells in a dose-dependent manner that had been activated by LPS [233,234]."
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"Furthermore, H 2 O 2 treatment increased the phosphorylation of p65 and IkappaBalpha, which were decreased when treated with N-acetyl cysteine or thymol."
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