IndraLab

Statements

USP8 ubiquitinates EGFR. 3 / 3
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"We conclude that UBPY negatively regulates the rate of EGFR down-regulation by deubiquitinating EGFR on endosomes."
16120644
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"By deubiquitinating EGFR on endosomes, USP8 prevents EGFR from degrading in lysosomes and reduces the rate of EGFR down-regulation after being stimulated with EGF [26,27] ."
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"Cell 16, 5163-5174) concludes that UBPY negatively regulates EGFR degradation by de-ubiquitinating the EGFR on endosomes, another report (Row, P. E., Prior, I. A., McCullough, J., Clague, M. J., and Urbe, S. (2006) J. Biol."
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