IndraLab

"Hence, interaction of TLR4, CD14, and CD11b/CD18 in murine macrophages treated with LPS or Taxol is proposed to deliver a coordinated set of intracellular signals that leads to the induction of the fu[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

"Additionally, Yao et al also confirmed that CD11b interacts with TLR4 and subsequently induces its endocytosis, which partially inhibits the interaction of lipopolysaccharide with TLR4 and the subsequent inflammatory response. xref Interestingly, TLR4 was not detected in our coimmunoprecipitation–MS analysis, which might be because of the transmembrane protein properties of both TLR4 and CD11b."

"TLR4 and ITGAM were strongly associated with macrophage polarization in the tumor microenvironment.[ xref ]The increased expression of ITGAM can decrease pulmonary inflammation and disruption of the endothelial cell barrier.[ xref ]ITGAM was identified as a serum exosomal protein marker of lung adenocarcinoma.[ xref ]ITGAM might be strongly linked to the carcinogenesis and the development of anaplastic thyroid cancer.[ xref ]The CCL2-CCR2 axis exerts 85 significant biological activities in dogs with metastatic OS.[ xref ]Inhibiting the TLR4 pathway of macrophages could achieve tumor inhibition.[ xref ]TLR4 activation may suppress the progression of OS via stimulating CD8 + cells.[ xref ]The antagonist LAG3 increased survival and antitumor immunity.[ xref ]The expression levels of PTPRC attenuates tumor development.[ xref ]Exogenous CD5 inhibits cell proliferation of hepatocellular carcinoma.[ xref ]These results suggested that 8 key pyroptosis genes were related to the progression of the respective cancers and the alteration of the tumor microenvironment."

"In addition, CoIP assay was performed to evaluate whether CD11b could interact with TLR4 after activated by LA1."

"Interestingly, activation of CD11b by LA1 could promote the interaction of CD11b and TLR4, and induce accumulation of TLR4 in endosomes."

"This could have implications for improving outcomes in acute inflammation and sepsis or in chronic disease as both CD11b and TLR4 are associated with these processes xref , xref ."

"The crosstalk between CD11b and TLR4 has been reported.[ xref ] Our results show significant increases in ROS production and CD11b activation in THP-1 cells when exposed to TAK242 ( xref – xref ), which was consistent with the previous knowledge of CD11b-TLR4 crosstalk as well as dexmedetomidine data."

"In the current study we started by investigating if the interaction of adsorbed Fg with monocytes was through TLR-4 and CD11b, the same receptors reported for the soluble Fg interaction with monocyte/[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

"Binding of dCyaA to CD11b and CD18 integrin may favor a TLR4 and CD11b interaction, or dCyaA could directly interact with TLR4 via its acyl chains."

"The interaction between LPS, CD11b, and TLR4 is still insufficiently understood."