IndraLab

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USP18 activates ZEB1. 3 / 3
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"Of note, USP18 functioned as the DUB of ZEB1 protein and enhanced the stability of ZEB1 protein, ultimately expediting ESCC cell invasion and metastasis [32]."
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"Our data demonstrated that the mRNA level of ZEB1 was not significantly different after alteration of USP18 in ESCC cells ( Supplementary Fig. 4 ), indicating that USP18 positively regulates ZEB1 at p[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In this cancer, USP18 enhances the protein stability of zinc finger E-box-binding homeobox 1 (ZEB1) through the decreased ubiquitination of ZEB1, increasing the migration and invasion abilities of ESCC cells [90]."
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