IndraLab

Statements

USP13 decreases the amount of MCL1. 2 / 2
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"In addition, genetic depletion of USP13 using clustered regularly interspaced palindromic repeats (CRISPR)/Cas9, or pharmacological inhibition of USP13 by a small-molecule inhibitor spautin-1, markedly downregulates MCL1 protein expression and shows synergistic effects against tumor cells in combination with ABT-263, a selective antagonist of BCL-2 and BCL-XL."
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"Interestingly, although USP13 depletion reduced MCL1 protein levels, neither cell proliferation nor cell migration was significantly changed under normal growth conditions."
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