IndraLab

Statements

USP13 decreases the amount of MCL1. 3 / 3
| 3
reach
"Interestingly, although USP13 depletion reduced MCL1 protein levels, neither cell proliferation nor cell migration was significantly changed under normal growth conditions."
29335437
reach
"Therefore, if USP13 inhibition reduces the protein level of MCL1, it significantly elevates cancer cell apoptosis."
37251574
reach
"In addition, genetic depletion of USP13 using clustered regularly interspaced palindromic repeats (CRISPR)/Cas9, or pharmacological inhibition of USP13 by a small-molecule inhibitor spautin-1, markedly downregulates MCL1 protein expression and shows synergistic effects against tumor cells in combination with ABT-263, a selective antagonist of BCL-2 and BCL-XL."
29335437