IndraLab

Statements

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"For example , inflammatory stimuli , e.g ., endotoxin and lipopolysaccharide ( LPS ) , have been shown to upregulate USP18 in peritoneal exudate macrophages ( 18 ) ."
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"USP18 is induced in hepatocytes by LPS and TNF-alpha but not by IL-6 and IL-10."
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"USP18 can also be induced by lipopolysaccharide ( LPS ) stimulation or virus infection ( Li et al ., 2016 ; MacParland et al ., 2016 ) ."
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"Usp18 is remarkably induced by type I and III IFNs , polyinosinic:polycytidylic acid (poly I:C) , tumor necrosis factor alpha (TNFα) , LPS , or genotoxic stresses ."
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"Bone marrow derived macrophages were isolated from wild type (WT), USP18 MKO or TAK1 MKO mice and treated with LPS or CpG, the expressions of cytokines including IL-6, IL-10, IL-1beta, and TNF-alpha were measured."
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"FIG 1 : USP18 expression is upregulated by TNF-alpha and LPS ."
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"Another major cluster, as shown in Fig. 3 C, was the genes up-regulated by LPS alone, encoding CXCL9–13, IFITM1–4, ISG15 or 20, USP18, PML, IRF7, OAS1, -2, or -L, IFI35, GBP1, etc., designated IFN-ind[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"For example, inflammatory stimuli, e.g., endotoxin and lipopolysaccharide (LPS), have been shown to upregulate USP18 in peritoneal exudate macrophages."
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"For example, inflammatory stimuli, e.g., endotoxin and lipopolysaccharide (LPS), have been shown to upregulate USP18 in peritoneal exudate macrophages."
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"LPS upregulates USP18 through IRF-3, while IRF-2 can reduce its inducing effect to a basic level."
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"Thus, Huh7.5 cells transfected with USP18 siRNA or control siRNA were treated with LPS (100 ng/ml), TNF-alpha (20 ng/ml), and/or IFN-alpha (100 IU/ml) for 2 h or pretreated with LPS (100 ng/ml) or TNF-alpha (20 ng/ml) for 24 h and then either left untreated or treated with IFN-alpha (100 IU/ml) for 2 h (a 2-h time point was selected for optimal expression of pSTAT1 in Huh7.5 cells)."
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"FIG 5 : IFN-alpha , LPS , and TNF-alpha do not induce type 1/2 IFN in primary murine hepatocytes but do induce USP18 ."
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"For example, LPS treatment of a murine macrophage cell line upregulates USP18 in an IRF3 dependent manner."
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"USP18 can also be induced by LPS [ 29 ]."
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"We next sought to determine whether TNF-alpha and LPS could induce USP18 expression in hepatocytes via the induction of IFN-alpha ."
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"Usp18 is strongly upregulated by type I and type III IFNs [ 33,35,37,51,52 ] , lipopolysaccharides [ 53,54 ] , polyI :C [ 53 ] , tumor necrosis factor alpha ( TNFalpha ) [ 54 ] , or genotoxic stresses [ 35,55 ] ."
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