IndraLab

Statements

USP5 inhibits Interferon. 10 / 10
| 10
reach
"We found that USP5 overexpression remarkably decreased the IFNα-induced pY701-STAT1 expression level ( Fig. 2 A)."
32683298
reach
"Recently, Liu et al. reported that human USP5 inhibited the IFN response by targeting RIG-I for degradation [ 27 ]."
32437860
reach
"Together, these data demonstrate that IFNs regulate the expression levels of USP5 and SMURF1 dynamically.Finally, since USP5 inhibits IFNα signaling and sustains SMURF1 turnover, we speculated that US[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
32683298
reach
"Our results showed that USP5 overexpression promotes virus replication and inhibits the IFNα-mediated antiviral activity as assessed by VSV-GFP replication in 293 T cells ( Fig. 7 A, B)."
32683298
reach
"Overexpression of USP5 from Lateolabrax japonicus significantly promoted RGNNV replication in vitro and inhibited the IFN immune response [ 10 ]."
35032679
reach
"Additionally, the sea perch ( Lateolabrax japonicus ) USP5 protein negatively regulates the red-spotted grouper nervous necrosis virus (RGNNV)-triggered IFN response [16] ."
32683298
reach
"Moreover, USP5 inhibited IFNα-induced pY701-STAT1 expression level in a dose-dependent manner and this inhibited effect relied on the enzyme catalytic activity of USP5 ( Fig. 2 )."
32683298
reach
"For example, human USP5 negatively regulated the IFN pathway by targeting RIG-I and IRF3 [ 27 , 28 ]."
32437860
reach
"Type I IFN plays an important role in antiviral infection process, and USP5 can inhibit the production of type I IFN."
33666082
reach
"It has been known that human USP5 can inhibit type I IFN signaling by negatively regulating RLRs signaling pathway [ 27 ]."
32437860