IndraLab

Statements

UBD activates OTULIN. 3 / 3
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"More strikingly, we found that OTULIN was directly activated by the bound diubiquitin."
26503766
reach
"More strikingly, we found that OTULIN was directly activated by the bound diubiquitin."
26503766
reach
"More strikingly, the structure also revealed that OTULIN is directly activated by the bound diubiquitin : placement of the proximal ubiquitin inserts the ubiquitin side chain of Glu16 directly into the active site of OTULIN, thereby pushing His339 into an active conformation and additionally co-ordinating the third catalytic residue, Asn341 (XREF_FIG)."
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