IndraLab

Statements



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"USP2 increases hepatic gluconeogenesis and exacerbates glucose intolerance in diet-induced obese mice (Molusky et al., 2012)."

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"Both circadian and USP2 deregulations accelerate the process of hepatic gluconeogenesis by increasing glucose secretion."

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"Thus, USP7 prevents T2DM by (1) improving insulin sensitivity, and (2) inhibiting gluconeogenesis.Previous reports have demonstrated that two additional USPs, namely USP2 and USP14, modulate hepatic gluconeogenesis [102,103]."

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"USP2 and 14 enhance gluconeogenesis, leading to high blood glucose levels."