IndraLab

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"To further determine how loss of BAP1 accelerates B cell lymphoma cells growth in vivo via regulating immune cell infiltration and TME, we conducted single-cell RNA-Seq (scRNA-seq) with the tumor samples from both BAP1-WT and -KO tissues (Supplemental Figure 5A)."
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"Interestingly, loss of BAP1 expression was found to promote T cell infiltration in uveal melanoma [79]."
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"Interestingly, recent research has revealed that the gain of chromosomal 8q may worsen prognosis by activating macrophage infiltration, and the loss of BAP1 expression may drive T cell infiltration in UM (Gezgin et al., 2017), suggesting that immune infiltration plays a crucial role in the prognosis of UM.Emerging evidence shows that the immune microenvironment is crucial for cancer progression and response to therapeutics (Quail and Joyce, 2013)."
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