IndraLab

Statements

USP22 activates FOXO1. 7 / 7
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"Oncogenic USP22 supports gastric cancer growth and metastasis by activating c-Myc/NAMPT/SIRT1-dependent FOXO1 and YAP signaling."
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"USP22 promotes GC progression by modulating FOXO1 or YAP signaling pathways via c-Myc/NAMPT/SIRT1."
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"Further IHC analysis confirmed that EPI treatment markedly increased the protein expression of USP22, FOXO1, and ATGL in xenograft MDA-MB-231 breast cancer tissues, while USP22 inhibition largely suppressed EPI-induced up-regulation of both FOXO1 and ATGL (Fig. 4, F to I)."
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"Western blot analysis of control and USP22-silenced GC cells showed that USP22 modulates the c-Myc/NAMPT/SIRT1-dependent FOXO1 and YAP signaling pathways."
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"Therefore, our data suggest that EPI promotes USP22-mediated FOXO1 protein stabilization for ATGL up-regulation in breast cancer cells."
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"USP22 maintained GC cell stemness by stabilizing BMI1 and promoted proliferation and metastasis by activating the FOXO1 and YAP signaling pathway [47,50]."
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"Collectively, our study revealed a previously unappreciated molecular mechanism underlying how USP22 controls EPI-induced cancer progression and metastasis through potentiating FOXO1-medited ATGL expression and lipolysis."
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