IndraLab

Statements

UCHL3 leads to the ubiquitination of AHR. 2 / 2
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"WT UCHL3, but not UCHL3-C95S, significantly reduced AhR protein polyubiquitination (Fig. 6f), whereas the other mutants did not decrease AhR polyubiquitination."
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"Correspondingly, TCID treatment reduced AhR protein levels and stemness-associated markers in UCHL3-overexpressing A549 cells without affecting AhR mRNA levels (Fig. 7b, c), suggesting that TCID, like UCHL3 knockdown, promotes AhR ubiquitination and degradation."
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