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Statements

CYLD activates ERK. 7 / 7
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"57 They reported that in human lung A549 cells and lungs of Cyld -/- mice, CYLD targets the activation of ERK."
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"Here, we examine both human lung epithelial A549 cells and lung of Cyld -/- mice to show that CYLD specifically targets the activation of ERK."
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"The finding that CYLD may target the ERK pathway in negatively controlling IL-8 expression is particularly significant."
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"However, it remained largely unknown whether or how CYLD modulated ERK signaling, when induced by bacterial pathogens."
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"Autophagy is an intrinsic defense mechanism against Lm and, therefore, we further investigated whether CYLD-dependent RIPK2 and ERK1/2 activation influences the formation of autophagosomes."
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"CYLD enhanced ERK- and p38/c-jun pathways in cardiomyocytes [76] (Fig. 2)."
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"However, because Cyld deficiency did not cause the activation of ERK, the target of CYLD might be an intermediate signaling factor specifically mediating the activation of JNK and IKKbeta."
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