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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

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INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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USP14 activates CREBBP. 3 / 3

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"Furthermore, we revealed a previously uncharacterized biological function of USP14 : Inhibition of USP14 reduced the stability of CBP, thereby lessening the severity of pathogen induced lung inflammation."

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"We found that the DUB USP14 targeted CBP for deubiquitylation, resulting in stabilization of CBP."

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"USP14 stabilizes CBP by diminishing its ubiquitination, whereas inhibiting USP14 deregulates the abundance of CBP and prevents LPS-mediated cytokine release."

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INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...

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Statements

USP14 activates CREBBP. 3 / 3

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