IndraLab

Statements

NAC inhibits JUN. 7 / 7
| 6 1
reach
"This work investigated the capacity of alpha-lipoic acid (LA) and N-acetyl-L-cysteine (NAC) to reduce zinc deficiency induced oxidative stress, and prevent the activation of nuclear factor-kappaB (NF-kappaB) and activator protein-1 (AP-1), and the cross-talk between both activated cascades through beta-Transducin Repeat containing Protein (beta-TrCP)."
16298762
reach
"At the molecular level, NAC has been shown to inhibit the activation of C Jun N-terminal kinase, p38 MAP kinase, redox sensitive activating protein-1 (AP-1) and the NF-kappaB transcriptional factor, thereby resulting in the suppression of numerous genes regulating the expression of many cytokines, such as TNF-alpha and IL-1 XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR."
25248126
reach
"Thus, NAC can inhibit activation of the JNK and c-Jun signaling pathway by reducing excessive ROS production, thereby reversing the cytotoxic effects of Dex."
33190410
reach
"NAC can inhibit activity of several signal transduction components such as nuclear factor kappa B, activator protein 1, and c- jun N-terminal kinase (JNK) by redox modulation [42, 43]."
10403520
reach
"NAC in combination with vanadate appeared to increase the efficacy of c-fos and c-jun inhibition, while decreasing toxicity."
17696279
sparser
"As shown in xref , both 15(S)-HETE and 15(S)-HPETE upregulated the mRNA levels of c-FOS and c-JUN, which was inhibited by NAC."
24732589
reach
"showed that the administration of N-acetylocysteine (NAC), a ROS scavenger, reduced colonic cancer cell apoptosis via inhibition of JNK, p38 MAPK and activation of c-jun."
24798211