IndraLab

Statements

FSCN1 increases the amount of KCNA2. 3 / 3
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"Ten-eleven translocation methylcytosine dioxygenase 1 (TET1), which can induce DNA demethylation, showed that overexpression in DRGs of rats can significantly alleviate L5 SNL-induced pain hypersensitivities by rescuing the expression of MOR and Kv1.2 during the development and maintenance periods while restoring morphine analgesia and attenuating morphine analgesic tolerance development [107]."
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"These increases are DNMT3a-dependent as blocking the SNL-induced upregulation in DRG DNMT3a abolished the SNL-induced elevation in Kcna2 DNA methylation level at these two CpG sites."
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"In addition, intrathecal BIX01294 blocked SNL-induced the increase of H3K9me2 and rescued the expression of Oprm1, Oprk1, Oprd1, Kcna2 and Kcna4 mRNAs in the injured DRG."
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