IndraLab

Statements

USP13 binds BECN1. 29 / 31
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"USP13 directly interacts with Beclin-1 and regulates de-ubiquitination of Beclin-1."
41484066
sparser
"USP13 can interact with Beclin1, deubiquitinate, and stabilize it (Liu et al. xref )."
36585612
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"Importantly, we identified a novel interaction between USP13 and Beclin-1, where USP13 facilitates the deubiquitination of Beclin-1, thereby promoting autophagy."
41484066
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"Furthermore, Beclin1 also interacts with USP13 and regulates the stability of USP13."
21962518
sparser
"USP13 interacts with Beclin 1 and stabilizes its expression, further regulating the expression of the Vps34 complex and p53."
38192665
sparser
"The Vps34 complexes can upregulate their expression by stabilizing the interaction between USP13 and Beclin 1, which in turn upregulates the expression of Beclin 1 by deubiquitination."
38192665
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"At the molecular level, the authors convincingly demonstrate that USP13 directly interacts with and deubiquitinates Beclin-1 (Figure 1B)."
36201669
sparser
"Mechanistically, USP13 interacted with Beclin-1, facilitating its deubiquitination and promoting autophagic flux, as shown by increased LC3 II/I ratios and decreased p62 levels."
41484066
sparser
"Intriguingly, a previous study revealed that USP13 and Beclin1 could interact with each other."
36188217
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"Moreover, USP13 directly interacts with Beclin 1 in untreated cells, while it dissociates from Beclin 1 after addition of Spautin-1 (XREF_FIG a)."
25545884
sparser
"Mechanistically, co-immunoprecipitation (Co-IP) and fluorescence co-localization assays revealed an interaction between USP13 and Beclin-1, suggesting that USP13 plays a role in the modulation of autophagy."
41484066
sparser
"Pharmacological inhibition of USP13 with spautin-1 reduced the levels of VPS34 complexes especially Beclin1 while overexpression of USP13 inhibited the ubiquitination degradation of Beclin1; on the other hand, the interaction of Beclin1 with USP13 significantly enhanced the DUB activity of USP13 ( xref )."
36188217
sparser
"Different truncation mutants of Beclin1 were coexpressed with USP13 in 293T cells and the interaction of USP13 with different Beclin1 mutants was analyzed by coimmunoprecipitation."
21962518
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"USP13 interacts with Beclin 1 and stabilizes its expression, further regulating the expression of the Vps34 complex and p53.The Vps34 complexes can upregulate their expression by stabilizing the interaction between USP13 and Beclin 1, which in turn upregulates the expression of Beclin 1 by deubiquitination."
38192665
sparser
"We found that endogenous Beclin1 can interact with USP13 and the interaction was reduced in the presence of spautin-1 ( xref )."
21962518
sparser
"Because a direct interaction of USP13 with Beclin 1 has been detected, it is thought that USP13 counteracts the ubiquitination of Beclin 1 by yet unknown ligases [ xref ]."
26445063
sparser
"These data suggest that Beclin1 may closely interact with USP13, whereas its interaction with USP10 is indirect or transient in nature."
21962518
sparser
"To further characterize the interaction of USP13 with Beclin1, we determined the domains of Beclin1 that interact with USP13 ( xref )."
21962518
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"Since DeltaC-Beclin1 can bind to Vps34 but not USP13, this experiment suggests that the interaction of Beclin1 and USP13 is critically important for regulating the stability of Vps34 complexes in response to spautin-1 treatment."
21962518
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"In 2011, Yuan et al. found that USP13 could interact with the C-terminal domain of Beclin-1 subunit in the VPS34 complex and deubiquitinate Beclin-1, thereby enhancing the stability of the VPS34 complex, which would contribute to the formation of autophagosomes (Liu et al., 2011)."
35445009
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"Interestingly, the DUB activities were significantly increased when USP13 and USP10 coincubated together or with Beclin1 or all 3 proteins together, suggesting the DUB activity can be significantly enhanced when USP13 interacts with its substrate Beclin1 or USP10."
21962518
sparser
"Furthermore, Beclin1 also interacts with USP13 and regulates the stability of USP13."
21962518
sparser
"Moreover, USP13 directly interacts with Beclin 1 in untreated cells, while it dissociates from Beclin 1 after addition of Spautin-1 ( xref a)."
25545884
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"Since the interaction of USP13 and Beclin1 is detectable by coimmunoprecipitation, we propose that Beclin1 may have close interaction with USP13."
21962518
sparser
"Since the interaction of USP13 and Beclin1 is detectable by coimmunoprecipitation, we propose that Beclin1 may have close interaction with USP13."
21962518
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"To determine the mechanism by which Vps34 complexes regulate the stability of USP13 and USP10, we examined the possibility that Beclin1 may interact with USP10 and USP13."
21962518
sparser
"Since ΔC-Beclin1 can bind to Vps34 ( xref ) but not USP13, this experiment suggests that the interaction of Beclin1 and USP13 is critically important for regulating the stability of Vps34 complexes in response to spautin-1 treatment."
21962518
sparser
"In 2011, Yuan et al. found that USP13 could interact with the C-terminal domain of Beclin-1 subunit in the VPS34 complex and deubiquitinate Beclin-1, thereby enhancing the stability of the VPS34 complex, which would contribute to the formation of autophagosomes ( xref )."
35445009
reach
"These data suggest that Beclin1 may closely interact with USP13, whereas its interaction with USP10 is indirect or transient in nature."
21962518