IndraLab

Statements

TP53 bound to E6 activates TP53. 5 / 5
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"The E6 protein binding to p53 causes p53 inactivation by its degradation, turning off its function [XREF_BIBR, XREF_BIBR]."
21718481
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"Nevertheless, the observed interaction between HSP90 and p53 and HPV16/18 E6 and E7 proteins indicates that HSP90 may prolong the presence of p53 and E6/E7 proteins in cells."
34928263
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"The E6 protein binding to p53 causes p53 inactivation by its degradation [XREF_BIBR, XREF_BIBR]."
21718481
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"E6 binding to p53 can also lead to retention of p53 in the cytoplasm, blocking its translocation to the nucleus and hence abrogating its function independently of degradation [XREF_BIBR]."
22829740
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"The newly transformed cells stably express E6, which binds to p53 and recruits the E3 ligase E6AP to target p53 for proteasomal degradation, as well as E7, which recruits the E3 ligase cullin 2 to target pRb for proteasomal degradation."
26008697