IndraLab

Statements

TP53 bound to E6 activates TP53. 4 / 4
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"The E6 protein binding to p53 causes p53 inactivation by its degradation [XREF_BIBR, XREF_BIBR]."
21718481
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"The E6 protein binding to p53 causes p53 inactivation by its degradation, turning off its function [XREF_BIBR, XREF_BIBR]."
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"E6 binding to p53 can also lead to retention of p53 in the cytoplasm, blocking its translocation to the nucleus and hence abrogating its function independently of degradation [XREF_BIBR]."
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"The newly transformed cells stably express E6, which binds to p53 and recruits the E3 ligase E6AP to target p53 for proteasomal degradation, as well as E7, which recruits the E3 ligase cullin 2 to target pRb for proteasomal degradation."
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