IndraLab

Statements

Mutated BAP1 activates Neoplasm Metastasis. 4 / 4
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"BAP1 mutations increase the risk of UVM metastasis and contribute to poor prognosis, while EIF1AX mutations are often associated with good prognosis."
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"XREF_BIBR Therefore, both somatic mutation of BAP1 in primary UM tumors and germline mutations increase the risk of metastasis and impart low survival rate."
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"Germline BAP1 mutations increased risk of metastasis independent of ciliary body involvement (P =.02)."
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"Moreover, in uveal melanoma, somatic BAP1 mutations cause metastasis with a probability of 74%, while the same has been observed in only 36% of the patients carrying a germline mutation [104]."
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