IndraLab

Statements

PRSS27 activates COPS5. 3 / 3
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"The increased flexibility of the MPN dimer allows CSN5 to recognize Nedd8 on CRL."
36041947
reach
"In our hands, mutation of the proteolytic MPN + domain, which is capable of cleaving Nedd8 and perhaps also other ubiquitin- or ubiquitin like moieties [XREF_BIBR], prevented the NF-kappaB suppressive effect of JAB1, indicating that it acts either via deneddylation of the SCF-complex or via de-ubiquitination e.g. of IkappaBalpha or other molecules involved in the regulation of NF-kappaB."
19656241
reach
"Thus, the N-terminal site does not appear to be involved in the interaction.In conclusion, we have identified a core MPN module of JAB1 as the binding region for MIF."
15757663