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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

PRSS27 activates COPS5. 1 / 1

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"In our hands, mutation of the proteolytic MPN + domain, which is capable of cleaving Nedd8 and perhaps also other ubiquitin- or ubiquitin like moieties [XREF_BIBR], prevented the NF-kappaB suppressive effect of JAB1, indicating that it acts either via deneddylation of the SCF-complex or via de-ubiquitination e.g. of IkappaBalpha or other molecules involved in the regulation of NF-kappaB."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...