IndraLab

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PRSS27 activates COPS5. 1 / 1

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"In our hands, mutation of the proteolytic MPN + domain, which is capable of cleaving Nedd8 and perhaps also other ubiquitin- or ubiquitin like moieties [XREF_BIBR], prevented the NF-kappaB suppressive effect of JAB1, indicating that it acts either via deneddylation of the SCF-complex or via de-ubiquitination e.g. of IkappaBalpha or other molecules involved in the regulation of NF-kappaB."

19656241

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IndraLab

Statements

PRSS27 activates COPS5. 1 / 1

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