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USP32 activates RAF/MEK/ERK. 4 / 4
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"Therefore, by deubiquitinating BAG3, we can show that USP32 can activate the RAF/MEK/ERK pathway.Finally, in order to investigate the relationship between USP32-BAG3, we first found that USP32 was positively correlated with the mRNA expression of BAG3 by analyzing the TCGA database, after which their positive correlation in protein levels was verified in various cell lines of NSCLC."
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"We conducted rescue studies in A549 and H1299 cells by transfecting with siControl or siUSP32 for 24 h, followed by transfecting with Flag or Flag-BAG3 to examine whether USP32 activates the RAF/MEK/ERK signaling cascade by increasing BAG3 expression in NSCLC cells."
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"In summary, these findings support our theory that USP32 regulates the level of BAG3 protein to activate the RAF/MEK/ERK signaling pathway."
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"These experimental results suggest that USP32 activates the RAF/MEK/ERK signaling pathway, which in turn promotes NSCLC cell proliferation, migration, and EMT progression through deubiquitination and stabilization of BAG3."
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