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IL1B binds CD4. 11 / 11
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"In xref and xref , it seems likely that IL-1β–expressing cells were associated with CD4 + cells, suggesting that the CD4 + cells might be involved, within the wall of the aneurysm, in activating IL-1β production in the dispersed macrophages and that, in turn, these cells might be activating the CD4 + cells, possibly through the presentation of autoantigens."
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"At the same time, RNA-Seq showed downregulated level of CD4 T cell-IL-1R2, which can competitively bind IL-1β from binding to IL-1R1 to negatively regulate IL-1β signaling (28), compared to the anti-IFNγ performed group ( Figure 5J )."
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"For Th17 polarizing conditions, CD4 + T cells were stimulated with plate bound anti-CD3 antibody (0.5 mug/ml) and anti-CD28 antibody (1 mug/ml) (BD Pharmingen), anti-IFN-gamma (2 mug/ml), anti-IL-4 (2[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Factors released from the interaction between IL-1β-competent myeloid cells and CD4 + T cells are highly toxic to neurons."
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"To evaluate the therapeutic potential of strategies that subvert the detrimental interaction between neutrophils and Fer-CD4 T cells in vivo , we crossed Cd4-Il1b Δ transgenic mice, in which IL1β + CD4 T lymphocytes were depleted, with spontaneously tumorigenic MMTV-PyMT mice (Supplementary Fig. S8A and S8B)."
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"The interaction between IL1B + TAMs and CD4 + T cells was notably upregulated via the CCL20-CCR6 axis related to inflammation [ xref ], which illustrates the inflammatory functions of IL1B + TAMs."
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"Immunofluorescence analysis of tumor samples showed a notable increase in the density of tumor-infiltrating CTLs in Cd4-Il1b Δ mice treated with chemotherapy compared with that in ADM-treated wild-type mice, whereas no discernible change was observed in the number of intratumoral CD4 T cells (Supplementary Fig. S8D)."
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"Moreover, tumor-infiltrating CD8 T cells not only increased in density but also exhibited increased synthesis of cytolytic cytokines, including perforin and granzyme B, in chemotherapy-treated Cd4-Il1b Δ mice ( xref ; Supplementary Fig. S8F)."
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"Furthermore, the IL10 receptor-IL10 pair emerged as a critical receptor-ligand mediating the interaction between IL1B + TAMs and CD4 + T cells."
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"Additionally, when neutrophils were eliminated from Cd4-Il1b Δ transgenic mice using Ly6G antibodies, neutrophil depletion exerted no discernible additive effects on tumor growth (Supplementary Fig. S8L), indicating that Fer-CD4 T cells regulate neutrophil functions."
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"Therefore, mPGES-1 stimulates an intercellular interaction between CD4 + T cells by upregulating the autocrine function of IL-1β in activated CD4 + T cells, which release IL-17 to facilitate axonal and myelin damage in EAE mice."
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